Using Data Science to Drive Precision Medicine
Daniel Rotroff is Assistant Staff in the Department of Quantitiative Health Sciences and Assistant Professor of Medicine at the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University.
My lab focuses on using computational approaches to investigate and better understand the development and treatment of complex diseases. We use a wide-range of computational and experimental approaches using -omics technologies to investigate many aspects of precision medicine, such as biomarker or risk allele discovery for both drug response and disease outcomes. We have several ongoing projects in the areas of type 2 diabetes, cardiovascular disease, obesity, hepatocellular carcinoma, among others. My graduate work was conducted at the University of North Carolina at Chapel Hill and at the National Center for Computational Toxicology at the US EPA. My postdoctoral work was spent in the Bioinformatics Research Center at North Carolina State University.
Understanding the genetic factors influencing drug response.
Identifying metabolite signatures of disease and drug response.
Using computational approaches to solve biological problems.
Identifying biological or biochemical pathways enriched in a cohort.
Selecting variables and developing models to build robust predictive tools.
Analysis and interpretation of complex clinical trial designs.
Taking experimental data from the bench to the patient's bedside.
Using naturally occuring diseases in animals to better understand human disorders.
Identifying subgroups within a general classification of disease.
Understanding heterogeneity in drug response and adverse outcomes in patients with T2D
Understanding the genetic etiology of drug response.
Discovering biomarkers to inform more targeted therapies.
Developing tools for more targeted treatments.
Using state-of-the-art approaches for predicting patient outcomes.
I'm sorry to say that we have no open positions at the moment. However, this could change at any point, so please check back often and thank you for your interest!
Daniel Rotroff, MSPH, PhD
Department of Quantitative Health Sciences
Lerner Research Institute
Assistant Professor of Medicine
Cleveland Clinic Lerner College of Medicine
Case Western Reserve University